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Lorazepam

Trade Names: Ativan

Class: Anticonvulsant, Sedative
Pharmacology:

Onset: 1-5 min IV 15-30 min IM
Duration: 6-8 hr

Binds to specific sites on the GABA Type A receptors and potentiate the effects of the GABA on the brain. Higher levels of GABA cause sedation
Indications:

Major Motor Seizures
Status Epilepticus
Premedication for Cardioversion
Acute Anxiety States

Contraindications:

Known Hypersensitivity

Cautions:

Should be diluted with NS of D5W
Flumazenil should be available
CNS Depressants and alcohol cause additive effects

Side Effects:

Hypotension
Drowsiness
Headache
Amnesia
Respiratory Depression
Blurred Vision
Nausea & Vomiting

Dosage:

Adult Seizure Activity: 0.5-2 mg IV

Special Considerations:

Pregnancy Safety: Category D
Short Acting drug; may require additional doses
Flumazenil should be available
Must be stored at 35-45 degrees F


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