Furosemide

Trade Name: Lasix

Class: Loop diuretic

Pharmacology:

  • Diuretic- inhibits sodium and chloride reabsorption in the proximal part of the ascending loop of hence and distal renal tubule, promoting excretion of sodium, water, chloride, and potassium.
  • Hyperkalemia – non potassium sparring diuretic therefore K+ leaves in the urine.
Packaging: 40mg/4mL amp
Indications:
  • Acute pulmonary edema (BP>90mmHg with signs of shock)
  • Hyperkalemia (adults only)

Contraindications:

  • Complete renal shutdown (non-acute anuria)
  • Hypokalemia
  • Severe hypovolemia, Hypotension, and dehydration
Dosages:
  • Adult: 0.5-1.0mg/kg IV over 1-2 minutes (start at 1.0mg/kg for hyperkalemia). If no response after 15-20 minutes double the dose up to 2mg/kg and IV over 1-2min
  • Pediatric: 1.0mg/kg IV/IM , Max dose 20mg IV
Precautions:
  • Watch for signs of electrolyte depletion and monitor ecg
  • Monitor for signs of ototoxicity (rapid admin)
  • Patients sensitive to sulfonamides
  • Elderly and debilitated patients