Epinephrine 1:10,000 Trade Name: Adrenaline (Epinephrine) 1:10,000 Sterile Solution Minijet

Epinephrine 1:10,000 Medication Class: Sympathomimetic

Epinephrine 1:10,000 Pharmacokinetics:

  • Onset: Subq – 5-10 min
  • IV/ET Tube – 1-2 min
  • Duration: 5-10 min
Stimulates alpha, beta1, and beta2 adrenergic receptors in dose related fashion. It is the initial drug of choice for treating bronchoconstriction and hypotension resulting from anaphylaxis and all forms of cardiac arrest.
Epinephrine 1:10,000 Indications:
  • Acute Allergic reaction
  • Cardiac arrest
  • Pulseless electrical activity
  • V Fib and pulseless V Tach unresponsive to initial defibrillation
  • Symptomatic bradycardia
  • Severe hypotension accompanied by bradycardia when pacing and atropine fail
  • Bronchial Asthma
Epinephrine 1:10,000 Contraindications:
  • Hypersensitivity (not an issue in emergencies – the dose should be lowered or given slowly in non cardiac arrest patients with heart disease)
  • Hypovolemic Shock (as with other catecholamines, correct hypovolemia 1st)
  • Coronary Insufficiency (Use with Caution) 

Epinephrine 1:10,000 Cautions:

  • MAO Inhibitors may potentate the effect of epinephrine
  • Beta-adrenergic antagonists may blunt inotropic response
  • Sympathomimetics and phosphodiesterase inhibitors may exacerbate dysrhythmia response
  • May be deactivated by alkaline solutions (sodium bicarbonate, furosemide)

Parenteral: 0.1 mg/mL ampule and pre-filled syringe
Auto injector: 0.3 mg/mL

Epinephrine 1:10,000 Administration:

  • Pulseless Arrest- Adult: IV/IO dose 1 mg(10 mL, 1:10,000) IV/IO push or ET Tube (2-2.5 mg diluted in 10 mL NS) Repeated every 3-5 min during resuscitation (Follow each IV dose with 20-mL saline flush); elevate arm for 20-30 sec after each dose; higher doses (up to 0.2 mg/kg) may be used for specific indications( ex: beta-blocker or calcium channel blocker overdose; poison/ drug induced shock)
  • Pediatric: IV/IO dose: 0.01 mg/kg every 3-5 min during arrest; max-dose 1 mg
    All ET doses: 0.1 mg/kg of 1:1000 every 5 min of arrest until IV/IO access then begin with first IV/IO dose
Epinephrine 1:10,000 Side Effects:
  • Headache
  • Nausea and vomiting
  • Restlessness
  • Weakness
  • Dysrhythmias, including V-tach and V-fib
  • Hypotension
  • Precipitation of angina pectoris
  • Tachycardia
  • Tremors
  • Dyspnea

Source: https://quizlet.com/27653697/paramedic-drug-cards-flash-cards/