Midazolam
Trade Names: Versed
Class: Sedative, Anticonvulsant, Hypnotic
Pharmacology:
Onset: 3-5 min IV 15 min IM
Duration: <2 hr IV 1-6 hr IM
Binds to specific sites on the GABA Type A receptors and potentiate the effects of the GABA on the brain. Higher levels of GABA cause hypnotic and sedation effects
Indications:
Premedication for Cardioversion
Premedication for other painful procedures
Seizures
Contraindications:
Known Hypersensitivity
Narrow Angle Glaucoma
Shock
Depressed Vital Signs
Alcoholic Coma
Cautions:
Flumazenil must be Available
May be Accentuated by CNS Depressants
Side Effects:
Laryngospasm
Bronchospasm
Respiratory Depression and Arrest
Drowsiness
Amnesia
Altered Mental Status
Bradycardia
Tachycardia
PVC’s
Retching
Administration:
- Adult Sedation: Typically 1-2.5 mg Slow IV 0.07-0.08 mg/kg IM
- Adult Anticonvulsant: >2.5 mg IV 10 mg IM
Special Considerations:
Pregnancy Safety: Category D
Emergency Resuscitative Equipment must be Available
Flumazenil must be Available
Dilute with NS or D5W prior to administration